Mechanisms of Itch Evoked by -Alanine
نویسندگان
چکیده
منابع مشابه
Electrically evoked itch in humans.
We compared itch sensations and axon reflex flare induced by transcutaneous electrical (0.08-8 ms, 2-200 Hz) and chemical (histamine iontophoresis; 100 microC) stimulation. Stimuli were applied to non-lesional volar wrist skin in 20 healthy human subjects and 10 patients with atopic dermatitis. Intensity of evoked itch and pain sensations were rated on a numerical rating scale (NRS) of 0 (no se...
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When a newly developed experimental method to vibrate vellus hairs on human skin was applied to the face and arm in healthy subjects, intense itch was reproducibly induced on the face, but not on the arm, without any flare reactions. In contrast to histamine-induced itch, mechanically evoked itch was not characterized as burning or stinging by any subjects, and was resistant to histamine H1-rec...
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Lightly touching normal skin near a site of itch can elicit itch sensation, a phenomenon known as alloknesis. To investigate the neural mechanisms of alloknesis, we have developed an animal model. Low-threshold mechanical stimulation of the skin normally does not elicit any response in naive C57/BL6 mice. Following acute intradermal (i.d.) injection of histamine in the rostral back, mechanical ...
متن کاملMolecular Mechanisms of Itch Sensations
OF THE DISSERTATION Molecular mechanisms of itch sensations By Seungil Kim Doctor of Philosophy in Biology and Biomedical Sciences (Developmental Biology) Washington University in St. Louis, 2011 Associate Professor James Skeath, Chairperson Itch is a sensation which causes scratching response to protect skin against external harmful reagents. Acute itch arises in short time period after insect...
متن کاملCowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.
Cowhage spicules provide an important model for histamine-independent itch. We determined that the active component of cowhage, termed mucunain, is a novel cysteine protease. We isolated mucunain and demonstrate that both native and recombinant mucunain evoke the same quality of itch in humans. We also show that mucunain is a ligand for protease-activated receptors two and four. These results s...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3509-12.2012